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The active comparator metformin (n=137) was administered at 500 mg twice daily initially and titrated up to 1000 mg twice daily (mean last dose 1365 mg). Amaryl may be used concomitantly with metformin when diet, exercise, and Amaryl or metformin alone do not result in adequate glycemic control. Initiation of rosiglitazone maleate/metformin hydrochloride in patients with established NYHA Class III or IV heart failure is contraindicated. The following information includes only the average doses of metformin and rosiglitazone. Furthermore, discontinuation or dose reduction of rosiglitazone maleate/metformin hydrochloride must be considered. In patients where monotherapy with Amaryl or metformin has not produced adequate glycemic control, the combination of Amaryl and metformin may have a synergistic effect, since both agents act to improve glucose tolerance by different primary mechanisms of action.

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